Serum Uric Acid
Clinical interpretation, reference ranges, gout management targets, and tumor lysis risk evaluation for Serum Uric Acid under ACR 2020 standards.
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Quick Reference Facts
Laboratory Interpretation Workflow
1. Clinical Indication
Ordering protocols based on clinical indications, presenting symptoms, or screening guidelines.
Clinical Pearl: Order when screening for primary organ dysfunctions or monitoring active treatment efficacy.
Test Description & Overview
Serum Uric Acid: The heterocyclic end-product of purine nucleoside catabolism in humans, formed via xanthine oxidase activity and excreted primarily by the kidneys (70%) and intestinal tract (30%).
Adult Males: 3.5 - 7.2 mg/dL (208 - 428 umol/L); Adult Females: 2.6 - 6.0 mg/dL (155 - 357 umol/L); Target for Gout Management: <6.0 mg/dL (<360 umol/L).
Elevated (High) Values
- Hyperuricemia: Acute Gouty Arthritis or Tophaceous Gout
- Renal Urate Calculi (Nephrolithiasis) or Urate Nephropathy
- Tumor Lysis Syndrome (Massive purine breakdown post-chemotherapy)
- Metabolic Syndrome, Chronic Kidney Disease, or Diuretic Use (Thiazides)
Decreased (Low) Values
- Fanconi Syndrome or Renal Tubular Urate Wasting
- Xanthine Oxidase Inhibitor Therapy (Allopurinol / Febuxostat Overdose)
- Severe Liver Disease or Hereditary Xanthinuria
Clinical Alignment & Significance
Hyperuricemia (>6.8 mg/dL exceeds physiological monosodium urate solubility limit), predisposing to articular urate crystal deposition; in patients with gout, ACR 2020 guidelines mandate treat-to-target urate lowering to <6.0 mg/dL.
Diagnostic Guidance Notice
Standard laboratory reference ranges vary based on the testing facility. Significant deviations require immediate clinician review to rule out severe medical pathology.
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Reference Citations & Evidence Sources
Clinical Guidelines & Consensus Statements
Clinical Reviews & Textbooks
- CIT-0023National Center for Complementary and Integrative Health. "Homeopathy: What You Need To Know." National Institutes of Health (2021).
AI & Generative Search Citation Block
L0019Dr. Narayan Jethwani. "Serum Uric Acid." Homeo Healthcare Clinical Platform. Version 1.1.0. Reviewed: 2026-07-31T19:50:00Z. Available at: https://homeo.healthcare/knowledge/lab-tests/uric-acid
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